Epigenetic profile of testicular germ cell tumours
نویسندگان
چکیده
منابع مشابه
Pathogenesis of testicular germ cell tumours.
Human germ cell tumours comprise a heterogeneous group of neoplasms. In the testis, three entities are distinguished, the teratomas-yolk sac tumours of the infantile testis, the seminomas and nonseminomas of adolescents and adults, and the spermatocytic seminomas. Studies on epidemiology, histology, clinical behaviour, and chromosomal constitution of these tumours support the concept of distinc...
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In testicular germ cell tumour (GCT), imaging plays a central role in assessment of tumour bulk, sites of metastases, monitoring response to therapy, surgical planning and accurate assessment of disease at relapse. The primary modality used for imaging patients with GCT is computed tomography (CT) but plain film radiography, ultrasound, magnetic resonance imaging (MRI) and positron emission tom...
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Over the past decade, accumulating evidence has implicated the phenomenon of epigenetic dysregulation in a variety of cancers (Biermann and Steger, 2007). Defined as the heritable changes in gene function that are not attributable to changes in DNA sequence, epigenetics involve biochemical modifications to DNA regulatory elements as well as to the tail regions of histone proteins (Maekawa and W...
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In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 1540 years. Its incidence has increased sharply in recent years. Fortunately, survival of patients with TGCT has improved enormously, which can chiefly be attributed to the cisplatin-based polychemotherapy that was introduced in the ninetee...
متن کاملFeatures of prognostic significance in testicular germ cell tumours.
One hundred and one testicular tumours previously diagnosed as "teratoma" were examined and 93 of the patients were followed up. These neoplasm were assigned to one of three groups. Those compared exclusively of somatic tissues were the only tumours referred to as teratoma. The second group was exclusively extra embryonic and consisted of either yolk sac or choriocarcinoma. Neoplasms in the thi...
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ژورنال
عنوان ژورنال: International Journal of Andrology
سال: 2007
ISSN: 0105-6263,1365-2605
DOI: 10.1111/j.1365-2605.2007.00754.x